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KMID : 1134820080370030269
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 3 p.269 ~ p.275
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Antioxidant Activities and Induction of Apoptosis by
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Lee Sung-Gyu
Yu Mi-Hee
Lee Sam-Pin
Lee In-Seon
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Abstract
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The avocado is a widely grown and consumed fruit that is high in nutrients and low in calories, sodium, and
fats. In this study, antioxidant activities and induction of apoptosis by methanol extracts from sarcocarp, seed and
peel of avocado were investigated in vitro. Contents of total polyphenols in methanol extracts from sarcocarp, seed
and peel were 13.89, 137.12 and 223.45 μg/mg respectively. Radical-scavenging activities of the methanol extracts
were examined by using α,α-diphenyl-β-picrylhydrazyl (DPPH) radicals and 2,2’-azino-bis(3-ethylbenzthiazoline-
6-sulfonic acid) (ABTS) assay. The methanol extracts from the peel of avocado showed higher scavenging activities
against DPPH, ABTS than those from sarcocarp and seed. Apoptosis in MDA-MB-231 cells mediated by the methanol
extracts of avocado was associated with the increase of activation of caspase-3 and caspase-3 target protein,
PARP. Therefore, with more researches on identification and action mechanism of active compounds, the methanol
extracts from peel and seed of avocado is expected to be a natural source for the developments of functional food
and medical agents to prevent human breast cancer.
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KEYWORD
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avocado, peel, seed, antioxidant, apoptosis
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